Mibelli's angiokeratoma D23.L7

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 20.05.2024

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Synonym(s)

angiokeratoma acroasphycticum digitorum; Mibelli type angiokeratosis

History
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Cottle, 1879; Mibelli, 1889

Definition
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Rare, autosomal-dominant, gynecotropic hereditary disease characterized by acrally localized multiple angiokeratomas.

Manifestation
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First occurrence often in puberty; predominantly in vagotonic patients with cold intolerance and a tendency to acrocyanosis and chilblains. The proximity to Aicardi-Goutières syndrome has been propagated (Cinotti E et al. 2021).

Localization
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Acral preference; especially fingers and toes, also elbows and knees.

Clinical features
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Mostly symmetrically arranged, at first flat, pinhead to lenticular erythema, later on blue-red papules with rough, sometimes also woolly surface.

Histology
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Circumscribed cavernous dilatations of capillary loops, acanthotic, hyperkeratotic epidermis.

Differential diagnosis
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Therapy
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If necessary, diathermy, laser treatment or excision if desired.

Literature
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  1. Cinotti E et al. (2021) Aicardi-Goutières syndrome: a possible explanation of angiokeratoma of Mibelli. J Eur Acad Dermatol Venereol 35:e770-e772.

  2. Cottle W (1879) Warty growths. St. Georges Hospital Reports 9: 753-762
  3. L'angiocheratoma. Giornale italiano di dermatologia e venereologia (Turin) 26: 159-180 and 260-276
  4. Mibelli V (1889) Di una nuova forma di cheratosi angiocheratoma. Giornale italiano di dermatologia e venereologia (Turin) 30: 285-301
  5. Sommer S et al. (2001) Severe predominantly acral variant of angiokeratoma of Mibelli: response to long-pulse Nd:YAG (1064 nm) laser treatment. J Am Acad Dermatol 45: 764-766

Incoming links (1)

Mibelli, vittorio;

Disclaimer

Please ask your physician for a reliable diagnosis. This website is only meant as a reference.

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Last updated on: 20.05.2024